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Updated: Jun 22, 2025

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
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Published on: December 16, 2016

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胎児のヘモグロビン誘導のためのWIZ転写因子の分子接着剤

Pamela Y Ting1, Sneha Borikar1, John Ryan Kerrigan1

  • 1Novartis Biomedical Research, Cambridge, MA, USA.

Science (New York, N.Y.)
|July 4, 2024
PubMed
まとめ

研究者達は,WIZタンパク質を分解する新しい分子接着剤,dWIZ-1とdWIZ-2を発見しました. この分解は,赤血球細胞における胎児のヘモグロビン (HbF) を効果的に誘導し,状細胞病 (SCD) の新しい有望な治療戦略を提供します.

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