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Updated: Jun 21, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

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アリルハリドを水性アンモニアと酸化水素基でパラジウム触媒化してアミネーションし,リガンド開発により可能

Kyoungmin Choi1, John N Brunn1, Kailaskumar Borate2

  • 1Department of Chemistry, University of California, Berkeley, California 94720, United States.

Journal of the American Chemical Society
|July 5, 2024
PubMed
まとめ

この研究は,水性アンモニアを用いた原発アリラミンの合成のための新しいパラジウム触媒法を示している. 新しい触媒システムは,水と水酸化物に関連した課題を効果的に克服し,効率的なアミネーション反応を可能にします.

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Preparation of Amines: Alkylation of Ammonia and Amines

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Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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