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Updated: Jun 21, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

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9-フローレノン電子シャトル触媒によって活性化されたアルディミンの可視光誘導エナチオセレクティブ・アサイレーションとアルキレーション

Ziwei Zhong1, Hongda Wu1, Xiaofan Chen1

  • 1Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.

Journal of the American Chemical Society
|July 9, 2024
PubMed
まとめ

研究者は,キラルアサイクリックα-三次性アミノケトンを合成するための新しい光触媒法を開発した. この可視光誘発反応は 高いステレオ制御で 価値ある医薬品の構成要素を 作り出すための強力な戦略です

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α-Alkylation of Ketones via Enolate Ions

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α-Substituted ketones or aldehydes can be synthesized from enamines by the Stork enamine reaction, named after its pioneer Gilbert Stork. Enamines are useful synthetic intermediates where the lone pair on nitrogen is in conjugation with the C=C bond. They resemble enolate ions, as the resonance forms of both species have a nucleophilic α carbon.
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