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Updated: Jun 21, 2025

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
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In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

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合理的に設計されたR2レトロトランポゾンによる哺乳類細胞における全RNA媒介標的遺伝子統合

Yangcan Chen1, Shengqiu Luo2, Yanping Hu1

  • 1Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; Bejing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.

Cell
|July 9, 2024
PubMed
まとめ

研究者は精密な遺伝子統合のためにR2レトロトランポゾンを使った全RNAシステムを設計した. この方法は高効率で特異性があり,リスクが軽減された遺伝子添加技術を進めている.

キーワード:
アルファフォールド2R2要素についてRNAドナー遺伝子編集遺伝子挿入遺伝子統合哺乳類の細胞タンパク質工学リトロトランスポゾン

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