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関連する概念動画

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Culturing and Measuring Fetal and Newborn Murine Long Bones
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Published on: April 26, 2019

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骨 を 作り上げる 母親 の 脳 の ホルモン

Muriel E Babey1, William C Krause2, Kun Chen3

  • 1Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Francisco, San Francisco, CA, USA.

Nature
|July 10, 2024
PubMed
まとめ

脳のニューロンからの細胞伝達ネットワーク因子3 (CCN3) は,授乳中の母親の骨を形成します. このホルモンは骨質を支えて 子孫の生存を保証し 骨の喪失に対する新たな治療法を 提供します

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科学分野:

  • 神経内分泌学
  • 骨格生物学
  • 生殖生物学

背景:

  • 哺乳期は,高カルシウム需要のため,母親の骨の減少が顕著である.
  • 産後エストロゲンのレベルが下がり 骨の保護が低下します
  • 以前に観察された女性特有の密度の高い骨のフェノタイプは ユーモラル要因が関与していることを示唆した.

研究 の 目的:

  • 哺乳期における骨質の調節に 責任のある体質因子を特定する.
  • 骨の代謝における脳由来細胞伝達ネットワーク因子3 (CCN3) の役割を調査する.
  • CCN3がオステオアナボリックホルモンとして作用するかどうかを判断する.

主な方法:

  • 弧状核KISS1 (ARCKISS1) ニューロンによって分泌される幽默因子としてのCCN3の識別.
  • マウスとヒトの骨格幹細胞の活性に対するCCN3の効果を in vitroで評価する.
  • マウスにおける骨の再構成と骨折修復に対するCCN3の影響を評価する.
  • 哺乳期のマウスのARCKISS1ニューロンのCCN3発現を操作する.

主要な成果:

  • CCN3は骨格幹細胞の活動と骨質コンドロゲン性を刺激する.
  • CCN3は,骨の再生を促進し,老いたマウスと若いマウスの両方で骨折の修復を加速します.
  • 授乳中の母親のCCN3濃度の低下は,低カルシウムダイエットで骨の減少と子孫の生存率の低下につながった.
  • 哺乳期にはARCKISS1ニューロンのCCN3発現が増加する.

結論:

  • CCN3は乳児の骨質維持に不可欠な,脳由来のアステオアナボリックホルモンです.
  • CCN3は子孫の生存に不可欠な母性ホルモンとして作用します.
  • CCN3は,両方の性別で骨の喪失を治療するための潜在的な治療目標です.