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Updated: Jun 21, 2025

Gene Transfer for Ischemic Heart Failure in a Preclinical Model
07:35

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炎症性サイトカインIgfbp7を標的とした心不全に対するワクチン療法

Manami Katoh1,2,3, Seitaro Nomura1,2,3, Shintaro Yamada1

  • 1Departments of Cardiovascular Medicine (M.Katoh, S.N., S.Y., M.I., M.Katagiri, T.H., T.F., N.T., T.K., K.F., B.Z., S.H., T.Y., S.I., Z.D., M.Kubota, K.S., H.M., I.K.), The University of Tokyo, Japan.

Circulation
|July 11, 2024
PubMed
まとめ

心臓の老朽化した内皮細胞 (ECs) は,心臓機能不全を悪化させるタンパク質であるIgfbp7を産生する. 新しいワクチンを用いてIgfbp7を標的にすることは,心不全を予防する新たな治療策となるかもしれません.

キーワード:
老化する心不全免疫療法酸化性リン酸化老化に関連した分泌現象型配列分析,RNA

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