Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

68.0K
Overview
68.0K
Tumor Immunotherapy01:27

Tumor Immunotherapy

509
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
509
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

886
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
886

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Multiplexed cytokine and antigen mRNA administration generates durable anti-tumor immunity against pancreatic cancer.

Nature communications·2026
Same author

Cellular nucleic acid-binding protein (CNBP) dependent cytokine programming shapes host defense against <i>Plasmodium</i> infection.

bioRxiv : the preprint server for biology·2026
Same author

Licensed to pore: Gasdermins in action.

Cell chemical biology·2026
Same author

Editorial Expression of Concern: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.

Nature immunology·2026
Same author

Lymph node-targeted DNA engages TBK1/IFN-I-driven innate immunity to induce potent T cell responses and durable memory in mice and NHPs.

Science advances·2026
Same author

Endothelial cell expression of STING<sup>V154M</sup>: Gain-of-function mutation delays the resolution of UVB-induced skin injury.

The Journal of investigative dermatology·2026

関連する実験動画

Updated: Jun 21, 2025

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
14:01

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

14.5K

免疫抑制を明らかにする

Jason R Pitarresi1, Katherine A Fitzgerald2

  • 1Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Science (New York, N.Y.)
|July 11, 2024
PubMed
まとめ

変異した代謝酵素を抑制することで,抗腫瘍免疫の有効性を回復させることができます. このアプローチにより 免疫系が より効果的にがんと闘うことができます

科学分野:

  • 免疫学
  • 代謝経路
  • 癌の研究

背景:

  • 癌細胞はしばしば 代謝経路を変えることで 免疫監視を回避します
  • 変異した代謝酵素は腫瘍の成長と免疫抑制に寄与する.

研究 の 目的:

  • 特定の変異した代謝酵素を標的とする可能性を調査する.
  • この酵素を阻害すると 抗腫瘍免疫反応が回復するかどうか

主な方法:

  • 特定の癌変異を持つ遺伝子組み換えマウスモデルを使用した.
  • 変異した代謝酵素を標的とする薬理学的阻害剤を使用した.
  • フロー・サイトメトリーと免疫ヒストケミストリーを用いて,腫瘍内の免疫細胞の浸透と活性を評価した.

主要な成果:

  • 変異した代謝酵素の抑制により,腫瘍の成長が著しく減少しました.
  • 腫瘍の微小環境内の細胞毒性Tリンパ球の浸透と活性化が回復した.
  • 腫瘍細胞による免疫抑制因子の発現が低下する.

結論:

  • 変異した代謝酵素を標的にすることは,抗腫瘍免疫を強化する有効な戦略です.

さらに関連する動画

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.2K
Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

8.2K

関連する実験動画

Last Updated: Jun 21, 2025

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
14:01

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

14.5K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.2K
Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

8.2K
  • 癌細胞に対する免疫認識と攻撃の回復は,代謝酵素の抑制によって達成可能である.