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Updated: Jun 20, 2025

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay

Published on: February 28, 2025

483

ストレンス・エネーブルド・サイクロプロパン・エレクトロフィルを用いてプロテオーム幅のリガンドとターゲット発見

Yue Liu1,2,3, Zhongtang Yu1,2,3, Peishan Li1,2,3

  • 1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.

Journal of the American Chemical Society
|July 17, 2024
PubMed
まとめ

研究者は化学生物学のために新しいサイクロプロパン基の電ophilesを開発しました. これらの探査機は,乳酸脱水素酵素A (LDHA) と粘着調節分子1 (ADRM1) のようなタンパク質における新しいシステイン標的を特定し,薬物発見を支援した.

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