関連する実験動画

Updated: May 8, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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生体内での単細胞CRISPRは,腫瘍の進化に特異的なTNFプログラムを発見する

Peter F Renz1, Umesh Ghoshdastider1, Simona Baghai Sain2

  • 1Institute for Regenerative Medicine (IREM), University of Zurich, Schlieren-Zurich, Switzerland.

Nature
|July 17, 2024
PubMed
まとめ

この研究は,腫瘍死滅因子 (TNF) が癌の進化過程で異なるシグナル伝達プログラムを明らかにしています. 新しい in vivo CRISPRスクリーンは,TNFシグナリングを,状細胞がんにおけるクローン拡大と侵入の原動力として特定しています.

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