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Updated: Aug 10, 2026

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
08:18

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene

Published on: December 31, 2014

細胞腫瘍遺伝子のp53は,突然変異によって活性化することができます

J R Jenkins, K Rudge, P Chumakov

    Nature
    |October 6, 1985
    PubMed
    まとめ

    腫瘍抑制タンパク質p53は,異なるメカニズムを通じて細胞を不死化させることができ,一部の突然変異はras oncogeneによるさらなる変換を防ぐ. これは,p53が細胞の不死化と腫瘍遺伝子の協力において異なる役割を担うことを示唆している.

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    Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

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