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関連する概念動画

DNA Packaging00:58

DNA Packaging

Overview
DNA Packaging00:58

DNA Packaging

Overview
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
DNA Topoisomerases02:02

DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types.  Type I...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

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関連する実験動画

Updated: May 8, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

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プログラム可能な表面修正によるイコサヘドラルDNAフレームワークのモジュール化された細胞内化行動

Kui Huang1, Qiulan Yang1, Min Bao1

  • 1Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Journal of the American Chemical Society
|July 22, 2024
PubMed
まとめ

DNAナノ構造の表面の変化は 細胞の吸収に大きく影響します リンガンドのタイプ,バレンンス,パターンを理解することは,これらのナノベーキルを用いて効果的な標的型遺伝子と薬物投与の鍵です.

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Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
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Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

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Simple, Affordable, and Modular Patterning of Cells using DNA
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Simple, Affordable, and Modular Patterning of Cells using DNA

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関連する実験動画

Last Updated: May 8, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.5K
Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
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Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

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Simple, Affordable, and Modular Patterning of Cells using DNA
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Simple, Affordable, and Modular Patterning of Cells using DNA

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科学分野:

  • バイオマテリアル科学
  • ナノテクノロジー
  • 細胞生物学

背景:

  • ナノ車両の表面改変は,標的の配送のための細胞内化を改善することができます.
  • リガンド認識,バレンス,パターンなどのパラメータは,特にDNAナノ構造のナノ構造内細胞化に影響を与えます.

研究 の 目的:

  • DNAナノ構造の細胞内化効率に表面修正パラメータがどのように影響するかを体系的に調査する.
  • 改造されたDNAナノ構造の内細胞経路と内部化後の運命を明らかにする.

主な方法:

  • 3つの異なるリガンドタイプを備えたイコサヘドラルDNAフレームワークを設計し,プログラムしました.
  • ナノ構造の表面でのリガンドのバレンスの多様性と空間的分布.
  • 細胞内化効率,内細胞経路,細胞内運命を分析した.

主要な成果:

  • リガンドのタイプ,バレンンス,空間的配置がナノ構造の内部化に大きく影響することを示した.
  • 特定された特定の内細胞経路は,異なる表面変異と関連しています.
  • DNAナノ構造の内部化後の行動についての洞察を提供した.

結論:

  • この研究は,DNAナノ構造の表面改変と細胞入りメカニズムの関係に関する理解を深める.
  • 標的細胞配送アプリケーションのための最適化DNAフレームワークナノ構造の設計に不可欠な洞察を提供します.