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Updated: Jul 11, 2026

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations
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パン癌単細胞解剖は,フェノタイプ的に異なるB細胞サブタイプを明らかにする

Yu Yang1, Xueyan Chen1, Jieying Pan2

  • 1Biomedical Pioneering Innovation Center (BIOPIC), Academy for Advanced Interdisciplinary Studies, and School of Life Sciences, Peking University, Beijing 100871, China.

Cell
|July 24, 2024
PubMed
まとめ

この研究では,腫瘍に浸透する様々なB細胞 (TIBs) が発見され,免疫療法の反応を予測する腫瘍関連非典型B細胞 (TAABs) のような新しい予後サブセットが特定されました.

キーワード:
非典型のB細胞パンガン分析単細胞RNAシーケンシング腫瘍に浸透するB細胞

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...