Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

12.4K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.4K
Master Transcription Regulators02:23

Master Transcription Regulators

6.1K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.1K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

2.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.0K
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

102
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

58
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
58

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

AAV vector production in suspension cells using PEI transfection and sodium butyrate with orthogonal assessment of function and quality.

Molecular therapy. Advances·2026
Same author

Double-Stranded DNA Sensing cGAS-STING Immune Signaling in a Rat Co-Culture Model of the Blood-Brain Barrier.

Cell biochemistry and function·2026
Same author

Hantavirus disease and the need for pathogenesis-guided therapy.

The Journal of experimental medicine·2026
Same author

4-Dimethylaminophenol: A 'Smaller'-Molecule PPI Inhibitor Targeting the PSD95 GK Domain Against Ischemic Stroke.

Angewandte Chemie (International ed. in English)·2026
Same author

Extended motif recognition tunes WW domain affinity in MAGI-IQSEC complexes.

The FEBS journal·2026
Same author

Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2.

Proceedings of the National Academy of Sciences of the United States of America·2026

関連する実験動画

Updated: May 2, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
11:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

11.1K

TMEFF1は,単純ヘルペスウイルスの神経特異的制限因子です.

Yao Dai1, Manja Idorn2,3, Manutea C Serrero2,3

  • 1Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.

Nature
|July 24, 2024
PubMed
まとめ

研究者らは,神経細胞特異のタンパク質であるTMEFF1が,ヘルペスシンプレックスウイルス1 (HSV-1) の複製を制限する重要な要因として作用することを発見しました. この発見は ウイルス感染や炎症に対する 脳の保護を理解するために不可欠です

さらに関連する動画

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
08:07

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Published on: February 17, 2016

71.9K
Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy
06:40

Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy

Published on: November 4, 2018

6.2K

関連する実験動画

Last Updated: May 2, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
11:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

11.1K
Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
08:07

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Published on: February 17, 2016

71.9K
Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy
06:40

Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy

Published on: November 4, 2018

6.2K

科学分野:

  • 神経ウイルス学
  • 免疫学
  • 遺伝学

背景:

  • 脳は感染や炎症による損傷に脆弱です.
  • ヘルペス・シンプレックスウイルス1 (HSV-1) は,ヘルペス・シンプレックス脳炎を引き起こす可能性があります.
  • ニューロン特異的な抗ウイルス因子の脳保護における役割は不明である.

研究 の 目的:

  • HSV-1の複製を制限する神経特有の抗ウイルス因子を特定する.
  • 中枢神経系におけるこれらの要因の 保護メカニズムを理解する

主な方法:

  • 制限因子を特定するための全ゲノムCRISPRスクリーニング
  • TMEFF1のノックアウトマウスを使って
  • ウイルスの侵入メカニズムと複製ダイナミクスの調査

主要な成果:

  • TMEFF1はHSV-1の制限因子として特定され,特に中枢神経系の神経細胞で発現した.
  • TMEFF1の減少はHSV-1の複製とニューロン死亡を増加させた.
  • TMEFF1は,ネクチン-1とミオシン重鎖との相互作用によって,HSV-1の侵入を阻害する.
  • Tmeff1のノックアウトマウスは,HSV-1に対する脳の感受性の増加を示した.

結論:

  • TMEFF1は,脳内のHSV-1に対する重要な神経特異的制限因子です.
  • TMEFF1は,過剰なウイルスの複製と神経損傷を防ぐ上で重要な役割を果たします.