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Updated: Jun 19, 2025

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
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Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

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膜アンカー支援ネイティブ・マススペクトロメトリーによって明らかになった難解なタンパク質-グリコスフィンゴリピド相互作用

James W Favell1, Duong T Bui1, Jianing Li1

  • 1Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.

Journal of the American Chemical Society
|July 25, 2024
PubMed
まとめ

新しい方法である膜アンカー支援原生質量スペクトロメトリー (MEAN-nMS) は,グリカン結合タンパク質 (GBPs) とグリコスフィンゴリピド (GSLs) の間の弱い相互作用の検出を強化します. このテクニックにより,細胞から直接GSLリガンドの敏感な識別が可能になり,グリコミクスの研究が進んでいます.

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