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Updated: Jun 18, 2025

In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity
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エピメリックタンパク質の運動解像度はステレオ選択的化学変異を可能にします

Guljannat Ablat1, Neev Lawton1, Ruqaiya Alam1

  • 1Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, U.K.

Journal of the American Chemical Society
|July 31, 2024
PubMed
まとめ

デヒドロアラニン (Dha) を用いた化学的変異は,エピメア混合物を生成する. 新しい方法は,アルカリ性d-ペプチダース (AD-P) を使用して,望ましくないd-同位体を除去し,ステレオ制御されたタンパク質工学を可能にします.

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