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関連する概念動画

Liver Physiology01:30

Liver Physiology

464
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
464
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

496
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
496
Liver Regeneration01:24

Liver Regeneration

3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
Liver Histology01:27

Liver Histology

661
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
661

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関連する実験動画

Updated: Jun 18, 2025

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

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急性肝不全

Rakhi Maiwall1, Anand V Kulkarni2, Juan Pablo Arab3

  • 1Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Lancet (London, England)
|August 4, 2024
PubMed
まとめ

急性肝不全 (ALF) は,迅速な診断と治療を必要とする深刻な状態です. 病気の様々な原因を理解し 早期治療を行うことは 患者の治療結果と生存率の改善に不可欠です

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Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
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Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
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Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

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Last Updated: Jun 18, 2025

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

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Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
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Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

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Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
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科学分野:

  • ヘパトロジー
  • クリティカル ケア 医療

背景:

  • 急性肝不全 (ALF) は,肝臓の機能が急激に低下し,肝臓の疾患は予備していない.
  • 血液凝固症と肝臓脳症で,死亡リスクが高い.

研究 の 目的:

  • ALFの様々な原因を 世界的に見直す
  • ALFの予測モデルと現在の管理戦略について議論する.
  • 早期発見と介入の重要性を強調する

主な方法:

  • ALFの原因,予後,治療に関する包括的な文献レビュー.
  • 薬物の毒性,ウイルス感染症,自己免疫疾患を含む一般的な病原体の分析.
  • サポートケア,肝臓移植,人工肝臓サポートシステムの評価

主要な成果:

  • ALFの原因は地域によって異なりますが,薬物毒性やウイルス感染症は一般的です.
  • セプシスと脳腫は,ALF患者の死亡の主な原因です.
  • 肝臓移植は 最良の治療法であり 血交換が有用であることが示されています

結論:

  • ALFの管理と予後を導くために,迅速な病因学的調査が不可欠です.
  • 早期発見と適切な治療 (移植を含む) は,ALFのアウトカムを大幅に変化させる可能性があります.
  • セプシスや脳腫などの 合併症を治療するには 多科目の治療が不可欠です