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Updated: Jun 17, 2025

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice
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Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice

Published on: January 31, 2020

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NKp46-活性化されたILC1sによる自己免疫器官損傷の増幅

Stylianos-Iason Biniaris-Georgallis1,2,3,4,5, Tom Aschman1,2,3,6,7, Katerina Stergioula1,2,3,4

  • 1Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin Campus Mitte, Berlin, Germany.

Nature
|August 13, 2024
PubMed
まとめ

組織に宿るNKp46+先天性リンパ球 (ILC) は,マクロファージの膨張と上皮細胞の損傷を促進することによって,性腎炎における腎臓の炎症を増幅する. NKp46のシグナル伝達を遮断することで 臓器の損傷が軽減され 新しい治療法が生まれます

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Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells08:22

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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD22608:30

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Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
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NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
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Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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