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Updated: Jun 17, 2025

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ノルエピネフリントランスポーターの基板結合および抑制メカニズム

Wenming Ji1, Anran Miao1, Kai Liang1

  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China.

Nature
|August 14, 2024
PubMed
まとめ

ヒトのノレピネフリントランスポーター (hNET) に関する構造的な洞察は,冷凍EMを用いて明らかにされた. これらの発見は,hNETが神経学的状態を理解するために不可欠な基板と阻害剤をどのように結合するのかを明らかにします.

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