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Updated: Jun 16, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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固体非共性有機二重ヘリックスフレームは非対称 [6 + 4] サイクル添加を触媒とする.

Tianyu Zheng1, Nils Nöthling1, Zikuan Wang1

  • 1Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr, Germany.

Science (New York, N.Y.)
|August 15, 2024
PubMed
まとめ

化学者は非共性有機構造から 新しい二重ヘリックス状の触媒を開発した. この触媒は,挑戦的な [6 + 4] サイクル添加を可能にし,価値ある 10 個のリングへの新しい経路を提供します.

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Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.
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