RESET-BP ランダム化臨床試験の結果
Bethany Barone Gibbs1, Subashan Perera2, Kimberly A Huber3
1Department of Epidemiology and Biostatistics (B.B.G.), West Virginia University, Morgantown.
Circulation
|August 21, 2024
まとめ
3ヶ月間静止状態 (SB) を減らしても,血圧 (BP) やパルス波速度 (PWV) は低下しませんでした. しかし,労働時間SBの減少は下流血圧と関連しており,PWVとの関連は昼間によって変化していた.
科学分野:
- 心血管の健康
- 労働衛生について
- 運動 生理学
背景:
- 静止行動 (SB) は心血管疾患のリスクと関連しているが,ランダム化試験からの因果的な証拠は限られている.
- 以前の観察研究では,静止時間と高血圧 (BP) とパルス波速度 (PWV) の間の関連が示唆されています.
研究 の 目的:
- 机上の作業員の静止行動 (SB) を減らし,血圧 (BP) と脈波速度 (PWV) を低下させることができるかどうかを調査する.
- SBを減らすための3ヶ月の介入が心血管のマーカーの改善につながるという仮説を検証する.
主な方法:
- 高血圧の271人のオフィスワーカー (年齢18~65歳) が参加した3ヶ月のランダム化臨床試験で,SB減少介入または対照群にランダム化されました.
- 介入グループは,毎日2〜4時間のSBを,コーチング,アクティビティプロンプト,座り立つのデスクを用いて立ち歩くことに置き換えました.
- 血圧 (BP) とパルス波速度 (PWV) は,発症初期と3ヶ月間,加速度計と臨床評価を用いて測定された.
主要な成果:
- この介入により,毎日のSBは約1.15時間減少し,主に労働時間中に立っている時間が増加したが,目標値を下回った.
- 静止状態のシストリックBP,静止状態のダイアストリックBP,24時間歩行中のBP,またはPWVにおいて,グループ間の有意な差異は観察されなかった.
- 労働時間SBの減少は,休息時の下痢血圧の減少と相関し,労働時間SBの減少は,PWVとの不利な関連を示し,非労働時間SBの減少は,有利な関連を示した.
結論:
- 作業中の静止状態を減らし,立ち上がりを増やす3ヶ月の介入は,血圧やPWVを低下させるのに効果的ではなかった.
- 将来の研究では,労働時間を超えてSBの削減戦略を探求し,労働時間と非労働期間のPWVの差異的な影響を明らかにする必要があります.
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