Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Adult Stem Cells01:33

Adult Stem Cells

28.1K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
28.1K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones.

Nature·2026
Same author

A high-fat, low-carbohydrate diet can feed intestinal tumours.

Nature·2026
Same author

<i>Clostridioides difficile</i> Stimulates <i>CCL20</i> Expression in Human Colonoid Monolayers in a Transwell-Based Coculture System That Supports Its Anaerobic Growth.

International journal of microbiology·2026
Same author

Impact of vitamin D on the colon cancer immune microenvironment: results of a randomized clinical trial of preoperative vitamin D supplementation in patients with stage I-III colon cancer.

Cancer discovery·2026
Same author

Correction: <sup>1</sup>H-NMR serum metabolomic profiling from clinical routine identifies signatures of progressive melanoma metastasis.

Scientific reports·2026
Same author

Small intestine microbiota development prevents early-life adiposity via IL-22-mediated intestinal PPARα suppression.

bioRxiv : the preprint server for biology·2026

関連する実験動画

Updated: Jun 15, 2025

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

2.2K

断食後の短期的な再給食は,ポリアミンを介して腸茎性を高める.

Shinya Imada1, Saleh Khawaled1, Heaji Shin1

  • 1Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.

Nature
|August 21, 2024
PubMed
まとめ

断食後の再給食はmTORC1とポリアミン代謝を活性化することで腸の幹細胞再生と腫瘍形成を促進します. これは食事による再生戦略における 潜在的な癌リスクを強調しています

さらに関連する動画

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
08:55

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

10.8K
Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures
08:53

Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures

Published on: November 3, 2014

16.2K

関連する実験動画

Last Updated: Jun 15, 2025

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

2.2K
Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
08:55

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

10.8K
Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures
08:53

Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures

Published on: November 3, 2014

16.2K

科学分野:

  • 細胞生物学
  • 胃腸内科
  • 腫瘍学

背景:

  • 断食は健康,寿命,組織再生を 改善することが知られている.
  • 大人の幹細胞と腫瘍形成に対する断食と再給食の影響は まだ十分に研究されていない.

研究 の 目的:

  • 断食後の再給餌が腸幹細胞 (ISC) の増殖と腫瘍形成にどのように影響するかを調査する.
  • これらの効果を誘発する 分子機構を解明するためです

主な方法:

  • マウスにおけるLgr5+腸内幹細胞 (ISC) への再給餌後の影響を研究した.
  • mTORC1のシグナル伝達,ポリアミン代謝,およびタンパク質合成の役割を調査した.
  • Apc遺伝子変異の文脈で腫瘍発生率を評価した.

主要な成果:

  • 断食後の再給食は,ISCの増殖と腫瘍形成を著しく増加させる.
  • この効果は,mTORC1誘導,ポリアミン代謝によるタンパク質合成の強化によって媒介されます.
  • リフェードされたISCにおけるAPC腫瘍抑制遺伝子の喪失は,より高い腫瘍発生率につながります.

結論:

  • 断食後の再栄養は 幹細胞の再生と腫瘍形成を促進する 独特の生理的状態を表します
  • 禁食と再給餌を伴うダイエット戦略は,がんリスクを軽減するために慎重に検討する必要があります.
  • mTORC1,ポリアミンの代謝,またはタンパク質合成をターゲットにすることで,治療の道を提供することができます.