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Autoimmune Disorders01:29

Autoimmune Disorders

398
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
398
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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What is the Immune System?01:38

What is the Immune System?

111.0K
Overview
111.0K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

781
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
781
Inflammatory Response01:28

Inflammatory Response

1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.9K
T Cell Types and Functions01:24

T Cell Types and Functions

963
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
963

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Updated: Jun 15, 2025

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

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自己免疫を停止する

Jon D Laman1, Michael Molloy2, Randolph J Noelle2,3

  • 1Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands.

Science (New York, N.Y.)
|August 22, 2024
PubMed
まとめ
この要約は機械生成です。

30年前に発見された CD40L 反抗薬は 自己免疫疾患の効果的な治療法として 登場しています これらの薬はCD40リガンド経路を標的とし 患者に新たな希望を与えています

さらに関連する動画

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

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Isolation and Th17 Differentiation of Na&#239;ve CD4 T Lymphocytes
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

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関連する実験動画

Last Updated: Jun 15, 2025

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

8.7K
High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

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Isolation and Th17 Differentiation of Na&#239;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

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科学分野:

  • 免疫学
  • 薬理学について

背景:

  • CD40リガンド (CD40L) 経路は免疫反応において重要な役割を果たします.
  • この経路の調節不良は,様々な自己免疫疾患の病原性に関与している.

研究 の 目的:

  • 自己免疫疾患におけるCD40L抗体の治療可能性を評価する.
  • CD40L経路を標的とした臨床的意義を強調する.

主な方法:

  • CD40Lアンタゴニストを含む臨床前試験と臨床試験のレビュー
  • これらの薬で標的となる免疫機構の分析

主要な成果:

  • CD40Lアンタゴニストは,自己免疫性の臨床前モデルにおいて有意な有効性を示した.
  • 臨床試験では,疾患の活動と症状を軽減する有望な結果が出ています.

結論:

  • CD40Lアンタゴニストは,自己免疫疾患の治療に有望な薬剤のクラスです.
  • CD40L経路を標的とした治療は 実行可能な治療戦略です