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Updated: Jun 15, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

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設計生物分子コンデンサートにおける相分離の調節可能なレバーとしての可逆性二硫化結合クロスリンク

Malay Mondal1,2, Penelope E Jankoski3, Landon D Lee1

  • 1Department of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States.

Journal of the American Chemical Society
|August 28, 2024
PubMed
まとめ

生物分子凝縮物 (BCs) のシステインは,二硫化結合を介して液体-液体相分離を促進し,共性ノードとして作用する. この発見は,BC形成と再酸化感受性物質の発達に関する新しい洞察を提供します.

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Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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Crossed Claisen condensations are base-promoted reactions between two different ester molecules producing β-dicarbonyl compounds.  The reaction involving esters, with both containing α hydrogen, results in a mixture of four different products that are difficult to isolate. This reduces the synthetic utility of the reaction.
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