関連する実験動画

Updated: Jun 14, 2025

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement
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Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement

Published on: January 19, 2017

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DNA複製のタイミングプログラム出現時に胚のゲノム不安定性

Saori Takahashi1, Hirohisa Kyogoku2,3, Takuya Hayakawa4

  • 1Laboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan.

Nature
|August 28, 2024
PubMed
まとめ

初期のマウス胚は DNAの複製が調整されていないために ゲノムが一時的に不安定になったことを示している. 複製の遅いフォークとDNAの損傷によって特徴づけられるこの不安定性は,8細胞段階によって解決され,ゲノムの完全性を確保します.

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Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization

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