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Updated: Jun 14, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

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分離可能なニッケル-アルキル複合体からの還元性アルキル-アルキル結合

Samir Al Zubaydi1, Shivam Waske1, Volkan Akyildiz1,2

  • 1Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.

Nature
|August 29, 2024
PubMed
まとめ

この研究は,伝統的な有機合成の限界を克服し,ニッケル触媒を用いて2つのアルキル基を組み合わせる多用途な方法を導入しています. このアプローチにより,アミン,酸,ハリドなどの一般的な構成要素から 複雑な分子を作ることができます.

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Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation

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Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
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Reducing carboxylic acid derivatives like acyl chlorides (RCOCl), esters (RCO2R′), and nitriles (RCN) using milder aluminum hydride agents like lithium tri-tert-butoxyaluminum hydride [LiAlH(O-t-Bu)3] and diisobutylaluminum hydride [DIBAL-H]...
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