関連する実験動画

Updated: Jun 14, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

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TGF-βとRASは,転移を誘導するプライム強化剤を共同で解明する

Jun Ho Lee1, Francisco J Sánchez-Rivera2, Lan He1

  • 1Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cell
|September 7, 2024
PubMed
まとめ

変換成長因子β (TGF-β) とRASシグナル伝達は,上皮からメゼンキマへの移行 (EMT) と細胞外マトリックス (ECM) の改造を調整することによって,肺腺がんの転移を誘導する. この研究は,この調整された転移プログラムを可能にする重要な染色体変異を特定します.

キーワード:
EMT についてRAS についてスマッドTGF-βクロマチン強化剤繊維症肺腺がん転移する

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