関連する実験動画

Updated: Jun 13, 2025

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

10.1K

IRS2シグナリングは,Ca2+ホメオスタシスを維持することによって,ストレス誘発性不律症から保護します

Qian Shi1, Jinxi Wang1, Hamza Malik1

  • 1Department of Internal Medicine (Q.S., J.W., H.M., X.L., J. Streeter, J. Sharafuddin, E.W., B.C., D.H., L.-S.S., E.D.A.), Carver College of Medicine, University of Iowa, Iowa City.

Circulation
|September 10, 2024
PubMed
まとめ

心臓インスリン受容体基質タンパク質-2 (IRS2) は,カルシウム処理を調節することにより,心律異常から保護します. 心臓細胞におけるIRS2の削除は不律症のリスクを高め,IRS2を心臓疾患の潜在的な治療標的として強調する.

キーワード:
心臓発作カルシウムカルシウムカルモジュリン依存タンパク質キナーゼ2型インスリン受容体基板タンパク質リアノジン受容体のカルシウム放出チャネル

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