関連する実験動画

Updated: Jun 13, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging

Published on: April 28, 2021

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DNA末端切除とDNA保護におけるBRCA1-BARD1機能のメカニズム

Ilaria Ceppi1, Maria Rosaria Dello Stritto1, Martin Mütze2

  • 1Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Bellinzona, Switzerland.

Nature
|September 11, 2024
PubMed
まとめ

BRCA1-BARD1複合体は,二重鎖破裂修復のためのDNA末端切除を直接促進する. その機能はRAD51の存在でDNA保護にシフトし,修復と複製フォークの安定性をバランスさせます.

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