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Updated: Jun 13, 2025

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
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Published on: June 26, 2020

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TEX264はDNAの修復と細胞の生存を促進するために,DNA損傷の選択的オートファギーを駆動します

Pauline Lascaux1, Gwendoline Hoslett1, Sara Tribble1

  • 1The MRC Weatherall Institute of Molecular Medicine, Department of Oncology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

Cell
|September 12, 2024
PubMed
まとめ

細胞リサイクルプロセスであるオートファギーは,リゾソーム内のトポイソメラーゼ1分裂複合体 (TOP1cc) を分解することによって,DNAの損傷を直接修復する. この発見により 細胞の生存とゲノムの安定性にとって 重要な新しいDNA修復経路が明らかになりました

キーワード:
DNA 修復DNA複製TEX264 について大腸がんゲノム安定性について核食タンパク質の分解選択的オートファジートポイソメラーゼ1分裂複合体ゼブラフィッシュ

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