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研究分野生物医学と臨床科学心血管医学と血液学心臓病 (心血管疾患を含む)
LMNA Q353R変異は,ビタミンDシグナル伝達障害による拡張性心筋病を引き起こす

LMNA Q353R変異は,ビタミンDシグナル伝達障害による拡張性心筋病を引き起こす

Masamichi Ito ^1,2, Manami Katoh ^1,3,4, Tatsuro Sassa ¹, Toshiyuki Ko ^1,3, Kanna Fujita ¹, Shintaro Yamada ¹, Koichiro Miura ⁵, Masashi Toyoda ⁶, Shuji Takada ⁷, Takashige Tobita ⁸, Mikako Katagiri ¹, Masayuki Kubota ¹, Takanobu Yamada ¹, Satoshi Hatsuse ¹, Hiroyuki Morita ¹, Masashi Ikeuchi ⁹, Katsuhisa Matsuura ⁵, Akihiro Umezawa ⁶, Seitaro Nomura ^1,3,4, Hiroyuki Aburatani ⁴, Issei Komuro ^1,3,10

Masamichi Ito ^1,2, Manami Katoh ^1,3,4, Tatsuro Sassa ¹

¹Department of Cardiovascular Medicine (M. Ito, M. Katoh, T.S., T.K., K.F., S.Y., M. Katagiri, M. Kubota, T.Y., S.H., H.M., S.N., I.K.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.
²Department of Advanced Clinical Science and Therapeutics (M. Ito), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.
³Department of Frontier Cardiovascular Science (M. Katoh, T.K., S.N., I.K.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.
⁴Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Japan (M. Katoh, S.N., H.A.).
⁵Institute of Advanced Biomedical Engineering and Science (K. Miura, K. Matsuura), Tokyo Women's Medical University, Shinjuku-ku, Japan.
⁶Center for Regenerative Medicine (M.T., A.U.), National Center for Child Health and Development Research Institute, Setagaya-ku, Tokyo, Japan.
⁷Department of Systems BioMedicine (S.T.), National Center for Child Health and Development Research Institute, Setagaya-ku, Tokyo, Japan.
⁸Department of Cardiology (T.T.), Tokyo Women's Medical University, Shinjuku-ku, Japan.
⁹Department of Biodesign, Division of Biofunctional Restoration Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Japan (M. Ikeuchi).
¹⁰International University of Health and Welfare, Minato-ku, Tokyo, Japan (I.K.).

⁰Department of Cardiovascular Medicine (M. Ito, M. Katoh, T.S., T.K., K.F., S.Y., M. Katagiri, M. Kubota, T.Y., S.H., H.M., S.N., I.K.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.

Circulation +

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2024年9月16日

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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

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In Vivo Modeling of the Morbid Human Genome using Danio rerio

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まとめ

No abstract available on PubMed

キーワード:

DNA 損傷心筋細胞拡大心筋病薬物スクリーニング心不全人間の誘発性多能幹細胞ビタミンD

関連する実験動画

自動的に一致したビデオです Contact us もしそれらが関連していない場合

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

<em>In Vivo</em> Modeling of the Morbid Human Genome using <em>Danio rerio</em>

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

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関連する概念動画

Satellite Stem Cells and Muscular Dystrophy

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

Translation

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...

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