関連する実験動画

Updated: Jun 12, 2025

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence
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生体内でのDNA複製ダイナミクスは,老化による複製ストレスを明らかにする.

Giacomo G Rossetti1, Noëlle Dommann2, Angeliki Karamichali1

  • 1Department of Molecular and Cellular Biology, University of Geneva, Geneva 1205, Switzerland.

Cell
|September 18, 2024
PubMed
まとめ

老化によりマウスの肝臓でのDNA複製の開始が妨げられ,複製のストレスを引き起こします. ATRの阻害は原発発射を回復したが,炎症を増加させ,ATRが年齢関連のストレスを軽減する役割を強調した.

キーワード:
ATR についてDNA複製DNA複製のストレス老化する謎めいたDNA損傷肝臓の再生複製の起源について部分肝切除手術

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