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Updated: Jun 12, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

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連続同位体ヘテロ[3]ロタキサンの簡潔で効率的な合成

Christopher K Lee1, Yuanning Feng2, Mohammad Tajik1

  • 1School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

Journal of the American Chemical Society
|September 21, 2024
PubMed
まとめ

研究者らは人工分子ポンプを開発し,機械的に相互接続した分子 (MIM) の正確なシーケンスイソマーを作成しました. 複雑で機能的な MIM 材料の合成を可能にします

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Selection Rules: Thermal Activation
Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
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In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
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