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関連する概念動画

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
Pre-mRNA Processing: RNA Splicing01:32

Pre-mRNA Processing: RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...

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関連する実験動画

Updated: Jun 7, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

ドロソフィラ・コリオンのトランスクリプトのスプライス・ジャンクション・シーケンスにおけるRNP粒子

Y N Osheim, O L Miller, A L Beyer

    Cell
    |November 1, 1985
    PubMed
    まとめ

    特定のリボヌクレオプロテイン (RNP) 粒子は,スプライス・ジャンクションで新生RNAトランスクリプトに結合する. これらのRNP粒子は,処理中にスプライスサイトを一緒に保持することによって,RNAスプライシングにおいて重要な役割を果たす可能性があります.

    科学分野:

    • 分子生物学は分子生物学である.
    • 遺伝学 遺伝学とは
    • バイオケミストリー バイオケミストリー

    背景:

    • 異質な核リボヌクレオプロテイン (HnRNP) 粒子は,新生RNAトランスクリプトに観察されています.
    • RNAのHnRNP粒子の結合部位の機能的意義は,まだ完全に解明されていない.

    研究 の 目的:

    • RNA処理におけるHnRNP粒子が結合する特定の配列の役割を調査する.
    • 新生トランスクリプトの形態を,ドロソフィラのコリオン遺伝子における核酸配列と相関させるため.

    主な方法:

    • 拡散クロマチンの電子顕微鏡可視化.
    • 新生トランスクリプトの形態学的相関は,ドロソフィラ・コリオンのs36-1およびs38-1遺伝子のヌクレオチド配列と相関する.

    主要な成果:

    • HnRNP粒子 (約1~3個) は,HnRNP粒子 (約1個) は,HnRNP粒子 (約1個) は,HnRNP粒子 (約1個) は,HnRNP粒子 (約1個) は,HnRNP粒子 (約1個) は,HnRNP粒子 (約1個) は,HnRNP粒子 (約1個) は,HnRNP粒子 (約1個) は,HnRNP粒子 (約1個) は,HnRNP粒子 (約1個) は, 25nm) は,新生コリオンのトランスクリプトにおけるイントロンのスプライス接合点に位置しています.
    • より大きな粒子 (約. 40nm),おそらく粒子の凝結によって形成され,スプライス・ジャンクション近くのより成熟したトランスクリプトで観察されています.

    さらに関連する動画

    Using the E1A Minigene Tool to Study mRNA Splicing Changes
    10:25

    Using the E1A Minigene Tool to Study mRNA Splicing Changes

    Published on: April 22, 2021

    Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster
    04:59

    Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster

    Published on: March 28, 2025

    関連する実験動画

    Last Updated: Jun 7, 2026

    Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
    11:34

    Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

    Published on: August 9, 2019

    Using the E1A Minigene Tool to Study mRNA Splicing Changes
    10:25

    Using the E1A Minigene Tool to Study mRNA Splicing Changes

    Published on: April 22, 2021

    Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster
    04:59

    Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster

    Published on: March 28, 2025

    結論:

    • スプライス・ジャンクションで観察されたRNP構造は,RNAスプライシングにおける役割を示唆しています.
    • これらの RNP 粒子は,バイパートイト スプライシングの際にスプライス・ジャンクションの結合と維持を容易にする可能性があります.