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Updated: Jun 11, 2025

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
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Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

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TET2によるRNA m5C酸化はクロマチンの状態と白血病発生を調節する

Zhongyu Zou1,2, Xiaoyang Dou1,2, Ying Li3

  • 1Department of Chemistry, The University of Chicago, Chicago, IL, USA.

Nature
|October 2, 2024
PubMed
まとめ

TET2変異は白血病の正常な染色体調節を乱します この研究は,TET2が通常,MBD6をレトロトランスポゾンRNA経由でクロマチンを開くのを防ぐことを明らかにし,TET2変異性骨髄性悪性腫瘍に新しい治療標的を提供している.

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