関連する実験動画

Updated: Jun 11, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

248

CTLA4阻害は,KEAP1/STK11に関連するPD-L) 1阻害剤に対する抵抗を無効化する

Ferdinandos Skoulidis1, Haniel A Araujo2, Minh Truong Do2

  • 1Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. fskoulidis@mdanderson.org.

Nature
|October 9, 2024
PubMed
まとめ

先進性非小細胞肺がん (NSCLC) とSTK11/KEAP1変異の患者は,ダブル免疫チェックポイントブロック (ICB) と化学療法から恩恵を受けます. この組み合わせは,PD- L) 1阻害剤のみに対する耐性を克服し,抗腫瘍活性を改善します.

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