関連する実験動画

Updated: Jun 10, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

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分子ダイナミクスは,二酸化葉酸還元酵素の表面上の活性が低下した阻害剤の多部位結合を明らかにする

Mitsugu Araki1, Toru Ekimoto2, Kazuhiro Takemura3,4

  • 1Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan.

Journal of the American Chemical Society
|October 12, 2024
PubMed
まとめ

薬剤耐性は,阻害剤の結合に影響するタンパク質変異から生じる. この研究は,二酸化葉酸還元酵素 (DHFR) の複数の結合状態を明らかにし,薬剤感受性の変化のための新しいモデルを提供している.

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