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Updated: Jun 10, 2025

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
08:48

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

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ヘパタイトス・デルタ・アンチゲンは,アセンブリドメインを唯一の固体として保持する

Yang Yang1, Marie-Laure Fogeron1, Alexander A Malär2

  • 1Molecular Microbiology and Structural Biochemistry (MMSB) UMR 5086 CNRS/Université de Lyon, Labex Ecofect, 7 Passage du Vercors, 69367 Lyon, France.

Journal of the American Chemical Society
|October 16, 2024
PubMed
まとめ

研究者は高度なNMRを用いて,肝炎デルタウイルス (HDV) のS- HDAgタンパク質を研究した. N端のアセンブリドメインは固体であり,残りのタンパク質は動的であり,ウイルスのRNP複合体への洞察を提供します.

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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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Interaction domains in cell signaling
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Protein Complex Assembly

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Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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