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リファキシミン予防は,最後の抗生物質のダプトマイシンに対する耐性を引き起こします

Adrianna M Turner1, Lucy Li1, Ian R Monk1

  • 1Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Nature
|October 24, 2024
PubMed
まとめ

抗生物質リファキシミンの使用は,バンコミシン耐性エンテロコッカス・フェシウム (VREfm) 感染に対する最後の手段であるダプトマイシンに対する耐性を意外に引き起こします. バクテリアのRNAポリメラーゼ変異によって引き起こされるこのクロスレジスタンスメカニズムは 抗生物質の有効性を脅かしています

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