関連する実験動画

Updated: Jun 9, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.0K

クロマチンの改造は,心不全における免疫細胞-繊維芽細胞の通信を駆動する

Michael Alexanian1,2,3, Arun Padmanabhan4,5,6,7, Tomohiro Nishino4,5

  • 1Gladstone Institutes, San Francisco, CA, USA. michael.alexanian@gladstone.ucsf.edu.

Nature
|October 24, 2024
PubMed
まとめ

研究者らは,マクロファージにおけるBrd4を阻害することで,インタールキン-1β (IL-1β) を標的として,心不全と線維細胞の活性化が減少することを発見した. これは心臓病における 線維症を誘発する 重要な炎症経路を明らかにしています

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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

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Assessing Cardiac Reprogramming using High Content Imaging Analysis

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