関連する実験動画

Updated: Jun 9, 2025

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
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Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay

Published on: November 11, 2018

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変異RASによるGTP水解の薬理学的回復

Antonio Cuevas-Navarro1, Yasin Pourfarjam1, Feng Hu1

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature
|October 30, 2024
PubMed
まとめ

新しいトライコンプレックス阻害剤は,GTPase活性を回復することによって,RAS変異がんに対する新しい治療戦略を提供します. これらの分子接着剤は,GTPの水解を刺激し,がん細胞の増殖を抑制するためにサイクロフィリンA (CYPA) を採用します.

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