慢性疾患から保護された最初の1000日間の砂糖配給への暴露
Tadeja Gracner1,2, Claire Boone3,4, Paul J Gertler5,6
1Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA, USA.
Science (New York, N.Y.)
|October 31, 2024
まとめ
2型糖尿病と高血圧のリスクを大幅に低下させた. 子宮内での被曝から観察されたこの保護は,長期的な健康のために早期の栄養の重要性を強調しています.
科学分野:
- 流行病学について
- 栄養学
- 公衆衛生
背景:
- 2型糖尿病と高血圧は 世界的な健康問題です
- 幼児期の栄養は 長期的な健康状態の決定的な要因として 認識されつつあります
- 人生の初期に確立された食事の摂取パターンは,持続的な代謝的な結果をもたらします.
研究 の 目的:
- 生後1000日間の砂糖制限が2型糖尿病と高血圧の発生リスクに及ぼす長期的な影響を調査する.
- 1953年に砂糖の配給が終了した後,英国の自然実験を利用して,これらの影響を評価する.
主な方法:
- 準実験的なイベント研究デザインを使用しました.
- 1953年9月に砂糖の配給が終了する直前と直後に生まれた個人を比較する英国バイオバンクのデータを用いた.
- 2型糖尿病と高血圧との関連を分析した.
主要な成果:
- 2型糖尿病のリスクは約35%,高血圧リスクは約20%減少した.
- 2型糖尿病では発症が約4年,高血圧では2年遅れた.
- 保護は子宮内での被曝で観察され,特に6ヶ月後の産後の砂糖制限によって増幅された.
結論:
- 妊娠後の最初の1000日間の砂糖の摂取を制限すると,2型糖尿病と高血圧から長期的に保護できます.
- 子宮内での砂糖の配給のみが,観察されたリスク減少に大きく寄与した.
- これらの発見は,慢性代謝疾患の予防における幼児の栄養の重要な役割を強調しています.
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