Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Mismatch Repair01:36

Mismatch Repair

39.9K
Overview
39.9K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

2.5K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.5K
Infection01:20

Infection

7.7K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.7K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

4.0K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.0K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

A randomized, double-blind, controlled, parallel group study with amustaline/glutathione pathogen reduced red blood cells in regions at potential risk for Zika virus transfusion-transmitted infections (RedeS Study)-protocol for a phase 3 clinical trial.

Trials·2026
Same author

A microbiologist's field guide to community ecology.

ISME communications·2026
Same author

The impact on image formation of inevitable tip bending with modern high resolution atomic force microscopy probes.

Nanoscale·2026
Same author

Mycobacterium smegmatis Expands Across Surfaces by Hydraulic Sliding.

Environmental microbiology reports·2025
Same author

Cell wall mechanical stress could coordinate septal synthesis and scission in <i>Staphylococcus aureus</i>.

mBio·2025
Same author

Assessing the Mechanism of Action of Synthetic Nanoengineered Antimicrobial Polymers against the Bacterial Membrane of <i>Pseudomonas aeruginosa</i>.

Biomacromolecules·2025

関連する実験動画

Updated: Jun 9, 2025

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.9K

2つの相互依存した経路が,高レベルのMRSAにつながります.

Abimbola Feyisara Adedeji-Olulana1, Katarzyna Wacnik2,3, Lucia Lafage2,3

  • 1School of Mathematical and Physical Sciences, University of Sheffield, Sheffield, UK.

Science (New York, N.Y.)
|October 31, 2024
PubMed
まとめ

メチシリン耐性ステーキ菌 (MRSA) は細胞分裂とペプチドグリカン構造を変化させ,抗生物質に抵抗します. これらの抵抗メカニズムを標的とする新薬は 治療の機会を提供します

さらに関連する動画

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus
09:03

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus

Published on: September 5, 2013

11.9K
Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
10:39

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus

Published on: March 10, 2017

16.6K

関連する実験動画

Last Updated: Jun 9, 2025

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.9K
Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus
09:03

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus

Published on: September 5, 2013

11.9K
Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
10:39

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus

Published on: March 10, 2017

16.6K

科学分野:

  • 微生物学
  • 分子生物学
  • 生物化学

背景:

  • メチシリン耐性ステーキ菌 (MRSA) は,ベータラクトーム抗生物質に対する耐性があるため,重大な臨床的脅威です.
  • この抵抗は主にペニシリン結合タンパク質2a (PBP2a) をコードするメカ遺伝子によってもたらされる.

研究 の 目的:

  • 抗生物質の存在下での生存と分裂を維持するためにMRSAが利用する細胞および分子メカニズムを調査する.
  • MRSAの抗生物質耐性戦略を理解することによって,潜在的な新しい治療標的を特定する.

主な方法:

  • 抗生物質の圧力下でのMRSA細胞分裂とペプチドグリカン合成の比較分析
  • ペニシリン結合タンパク質 (PBP) の遺伝子解析と補償変異の特定

主要な成果:

  • MRSAは,抗生物質にさらされると,細胞分裂モードと分裂隔膜のペプチドグリカン構造が変化します.
  • PBP2aはPBP2のトランスペプチダース活性に取って代わることができるが,PBP1のトランスペプチダース活性に取って代わることはできない.
  • 染色体増強剤 (ポット) 変異は,PBP1の活性がない場合でもMRSA分裂を可能にします.

結論:

  • MRSAは,PBP2aの活性と,高いレベルの抗生物質耐性のための別の分裂経路を含む二重メカニズムを使用します.
  • これらの相互に関連した耐性メカニズムをターゲットにすることで,新しいMRSA再敏感剤を開発するための有望な戦略を示しています.