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Updated: Jun 9, 2025

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卵巣がんに由来するIL-4は,免疫療法に対する耐性を促進する

Gurkan Mollaoglu1, Alexander Tepper2, Chiara Falcomatà2

  • 1Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Cell
|October 31, 2024
PubMed
まとめ

卵巣がん細胞からのインタールイキン-4 (IL-4) は,免疫抑制性腫瘍微環境 (TME) を作り,免疫療法に対する耐性を引き起こす. 抗PD-1 治療の有効性を向上させる可能性があります.

キーワード:
CCL7 についてIL-4 についてパートルブマップ免疫療法腫瘍内異質性マクロファージマルチプレックスイメージング卵巣がん空間的なCRISPRスクリーン空間ゲノミクス腫瘍免疫学腫瘍の微小環境腫瘍地域タイプ2の免疫

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