関連する実験動画

Updated: Jun 8, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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TRIM21ベースの分子接着剤とPROTAC分解剤によるマルチメリックタンパク質の選択的分解

Panrui Lu1, Yalong Cheng2, Lei Xue1

  • 1Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China; National Institute of Biological Sciences, Beijing 102206, China.

Cell
|November 2, 2024
PubMed
まとめ

新しい分子接着剤 (S) -ACE-OHはTRIM21を標的とし,核孔タンパク質を分解する. このアプローチにより,疾患に関連したタンパク質の分解が可能になり,様々な疾患に対する新しい治療戦略が提供されます.

キーワード:
E3ユビキチンリガゼプロタックトリム21バイオ分子凝縮物分子接着剤マルチメリックタンパク質核孔複合体標的型タンパク質の分解

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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes07:22

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Assays for the Degradation of Misfolded Proteins in Cells10:56

Assays for the Degradation of Misfolded Proteins in Cells

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