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Updated: Jun 8, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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タイプIIIインターフェロンは,腸内皮質細胞のピロプトーシスを誘発し,粘膜の修復を阻害する

Kautilya K Jena1, Julien Mambu2, Daniel Boehmer3

  • 1Division of Immunology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA.

Cell
|November 5, 2024
PubMed
まとめ

タイプIやIIのインターフェロンは,Z-DNA結合タンパク質1 (ZBP1) を上調することで腸の修復を阻害し,熱死を引き起こし,治癒を遅らせます. この経路は炎症性腸疾患 (IBD) に関わっている.

キーワード:
Z核酸大腸炎損傷ガスダーミン炎症炎症性腸疾患インターフェロン腸内皮質細胞腸の幹細胞放射線照射パターン認識受容器ピロプトーシス修理する

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