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Updated: Jun 8, 2025

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
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Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

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カルシネウリンとPKAの間のポストシナプス競争は,哺乳類の睡眠-覚醒サイクルを調節する

Yimeng Wang1, Siyu Cao1, Daisuke Tone1,2

  • 1Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Nature
|November 7, 2024
PubMed
まとめ

タンパク質キナーゼA (PKA) は覚醒を促進し,タンパク質フォスファタゼPP1とカルシヌーリンはシナプスタンパク質のリン酸化を調節することによって睡眠を促進する. 興奮後シナプスにおけるこれらの反作用は睡眠期間を制御する.

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