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Updated: Jun 8, 2025

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
09:35

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

11.4K

C-H機能化によって促進された (-) -シリンドロサイクロファンAの総合成

Aaron T Bosse1, Liam R Hunt2, Camila A Suarez1,2

  • 1Department of Chemistry, Emory University, Atlanta, GA 30322, USA.

Science (New York, N.Y.)
|November 7, 2024
PubMed
まとめ

研究者は,複雑なマクロサイクルである (-) - シリンドロサイクロファンAの効率的な17段階の合成を開発しました. この簡素化された経路は,高度なステレオ選択性のために高度なC-H機能化とクロスカップリング反応を使用します.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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Removing one hydrogen from the intervening CH2 group...
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