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Updated: Jun 7, 2025

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
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スケーラブルチオール反応性プロファイリングは,アゼチデニルオキサディアゾールをシステインを標的とする電子性として識別する

Fereshte Ghorbani1, Shaochen You1, Gennadii A Grabovyi2

  • 1Department of Chemistry, Scripps Research, San Diego, California 92037, United States.

Journal of the American Chemical Society
|November 14, 2024
PubMed
まとめ

研究者は新しいシステイン反応性分子を見つけるために,スケーラブルチオール反応性 (STRP) を開発した. この方法では,システイン残基を共性的に変異するアゼチジニルオキサディアゾールを特定し,薬物の発見とプロテオーム全体のシステイン結合を可能にしました.

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