Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

The Central Dogma01:25

The Central Dogma

124.0K
Overview
124.0K
From DNA to Protein03:06

From DNA to Protein

18.0K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
18.0K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

12.0K
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...
12.0K
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

11.9K
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
11.9K
Cellular Differentiation00:57

Cellular Differentiation

2.6K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
2.6K
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

5.1K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
5.1K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Reciprocal repulsions enforce heterotypic dendrite segregation in an olfactory circuit.

bioRxiv : the preprint server for biology·2026
Same author

Engulfment by brain macrophages in a short-lived vertebrate.

bioRxiv : the preprint server for biology·2026
Same author

TranscriptFormer: A generative cell atlas across 1.5 billion years of evolution.

Science (New York, N.Y.)·2026
Same author

Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV.

PLoS pathogens·2026
Same author

Tabula Sapiens reveals the non-coding RNA landscape across 22 human organs and tissues.

bioRxiv : the preprint server for biology·2026
Same author

Scalable single-cell total RNA sequencing unifies coding and noncoding transcriptomics.

Nature biotechnology·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
関連記事をすべて見る

関連する実験動画

Updated: Jun 7, 2025

Simple, Affordable, and Modular Patterning of Cells using DNA
08:59

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

4.1K

細胞のドグマ

Stephen R Quake1

  • 1The Chan Zuckerberg Initiative, Redwood City, CA, USA; Depts of Bioengineering and Applied Physics, Stanford University, Stanford, CA, USA.

Cell
|November 15, 2024
PubMed
まとめ
この要約は機械生成です。

細胞の情報流の理解は 次の10年間の大規模な生物学的課題となります このコンセプトはクリックの中央ドグマにインスパイアされ,細胞内の一般的な情報転送に焦点を当てています.

さらに関連する動画

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy
12:15

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy

Published on: October 3, 2017

13.4K
Rapid Development of Cell State Identification Circuits with Poly-Transfection
09:21

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Published on: February 24, 2023

1.5K

関連する実験動画

Last Updated: Jun 7, 2025

Simple, Affordable, and Modular Patterning of Cells using DNA
08:59

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

4.1K
The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy
12:15

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy

Published on: October 3, 2017

13.4K
Rapid Development of Cell State Identification Circuits with Poly-Transfection
09:21

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Published on: February 24, 2023

1.5K

科学分野:

  • 分子生物学
  • 細胞生物学
  • システム生物学

背景:

  • フランシス・クリックの"中央教義"は 分子情報の流れを理解するための基本的枠組みを提供した.
  • その後の発見は,この教義を拡張し,精錬しました.
  • 情報の流れを全面的に理解することは,現代生物学における重要な課題です.

研究 の 目的:

  • 生物学的研究における主要な概念的課題を特定し,明確に述べる.
  • 細胞内の情報流の理解に重点を置いた研究課題を提案する.
  • 未来の研究を導くために セントラル・ドグマのような基本概念からインスピレーションを得ること

主な方法:

  • 既存の生物学的知識の概念的分析と合成
  • 細胞情報処理の現在のモデルにおけるギャップと限界を特定する.
  • 情報流のより一般的な理解のための枠組みの開発.

主要な成果:

  • 細胞の情報フローを理解するにあたって,大きな概念的な課題が特定されています.
  • 提案された課題は,伝統的な分子経路を超えて,一般的な見方を強調しています.
  • フレームワークは,情報転送を研究するための学際的なアプローチを奨励しています.

結論:

  • 細胞情報フローの課題に取り組むことは 生物学の進歩に不可欠です
  • 細胞情報の複雑さを完全に理解するには 一般的な視点が必要です
  • 将来の研究は,情報転送の多様なメカニズムを統合することに重点を置くべきです.