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関連する概念動画

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

178
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Regulation of Metabolism01:19

Regulation of Metabolism

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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Protein Modifications in the RER01:26

Protein Modifications in the RER

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Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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Protein Folding Quality Check in the RER01:29

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ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
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Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
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関連する実験動画

Updated: Jun 7, 2025

Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability
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バイオエンティティの安定性と機能性を高めるための網状化学

Mengchu Feng1, Chunyan Xing1, Yehao Jin1

  • 1Frontiers Science Center for High Energy Material, Advanced Technology Research Institute (Jinan), Key Laboratory of Cluster Science (Ministry of Education), Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Advanced Research Institute of Multidisciplinary Science, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China.

Journal of the American Chemical Society
|November 19, 2024
PubMed
まとめ

メタル・オーガニック・フレームワーク (MOF) とコヴァレンント・オーガニック・フレームワーク (COF) を用いた網状化学は脆弱な生物体を安定させる. これらの高度な材料は 生物体の安定性,活性,および用途を高めます

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科学分野:

  • 材料科学
  • バイオテクノロジー
  • 化学について

背景:

  • 酵素や細胞のような生物体は しばしば脆弱で 貯蔵や適用中に安定性や性能を制限します
  • 網膜化学は バイオエンティティの安定化と強化のための 毛細なフレームワークを提供します

研究 の 目的:

  • ネットワークの枠組み (MOFとCOF) にバイオエンティティを統合するための戦略を概説する.
  • これらの枠組みの中でバイオエンティティのパフォーマンスを高めるための新しいデザインのアイデアを強調する.
  • バイオエンティティの応用範囲を広げるために,これらのバイオ複合材料の可能性を議論する.

主な方法:

  • メタル・オーガニック・フレームワーク (MOF) とコヴァレンント・オーガニック・フレームワーク (COF) の内でのバイオエンティティの統合.
  • フレームワークの多孔性を利用して 効率的な負荷,質量移転,閉じ込め.
  • バイオエンティティの機能を最適化するために バイオインタフェースの相互作用とマイクロ環境の調整

主要な成果:

  • 網状のフレームワークは,生物体の安定性を大幅に高め,分解から保護します.
  • フレームワークはバイオエンティティの活動を促進し,非ネイティブの機能を伝えることができます.
  • これらのバイオコンポジットは バイオエンティティのシステム内の 協同作用を可能にします

結論:

  • 網状のフレームワークは,高性能のバイオベースの材料を開発するための強力なプラットフォームを提供します.
  • この分野を進めるには,設計,特徴付け,応用に関するさらなる研究が不可欠です.
  • バイオコンポジットは バイオテクノロジーの様々な用途に 期待されています